Varaico: Literature-Extracted Genetic Variants

MCM4

185 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 163–264UCSCMCM N-terminal domain

MCM_OBaa 270–398UCSCMCM OB domain

MCMaa 445–670UCSCMCM P-loop domain

MCM_lidaa 685–769UCSCMCM AAA-lid domain

WHD_MCM4aa 792–862UCSCMCM4, winged helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 4

HGNC Previous Symbol

CDC21

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_182746.3

p.G93S

c.277G>A

Surrounding Variants

1 paper

NM_182746.3

p.R98W

c.292C>T

1 paper

NM_182746.3

p.L82F

c.244C>T

1 paper

NM_182746.3

p.R104R

c.312A>G

1 paper

NM_182746.3

p.R108W

c.322A>T

1 paper

NM_182746.3

p.A135V

c.404C>T

1 paper

NM_182746.3

p.D138G

c.413A>G

1 paper

NM_182746.3

p.I139V

c.415A>G

1 paper

NM_182746.3

p.A141G

c.422C>G

1 paper

NM_182746.3

p.S142fs

c.424_425fs

1 paper

NM_182746.3

p.S142N

c.425G>A

1 paper

NM_182746.3

p.L146L

c.438A>G

1 paper

NM_182746.3

p.I152T

c.455T>C