Varaico: Literature-Extracted Genetic Variants

MCM4

185 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 163–264UCSCMCM N-terminal domain

MCM_OBaa 270–398UCSCMCM OB domain

MCMaa 445–670UCSCMCM P-loop domain

MCM_lidaa 685–769UCSCMCM AAA-lid domain

WHD_MCM4aa 792–862UCSCMCM4, winged helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 4

HGNC Previous Symbol

CDC21

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_182746.3

p.I283T

c.848T>C

Surrounding Variants

1 paper

NM_182746.3

p.I283L

c.847A>C

1 paper

NM_182746.3

p.T284I

c.851C>T

1 paper

NM_182746.3

p.S286S

c.858C>T

1 paper

NM_182746.3

p.R291S

c.873G>C

1 paper

NM_182746.3

p.T292insFs

c.874_875ins4

1 paper

NM_182746.3

p.R291S

c.873G>T

1 paper

NM_182746.3

p.F303Y

c.908T>A

1 paper

NM_182746.3

p.Q305E

c.913C>G

1 paper

NM_182746.3

p.T312M

c.935C>T

1 paper

NM_182746.3

p.E316D

c.948G>C

1 paper

NM_182746.3

p.E316D

c.948G>T

1 paper

NM_182746.3

p.R319C

c.955C>T