Varaico: Literature-Extracted Genetic Variants

MCM4

185 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 163–264UCSCMCM N-terminal domain

MCM_OBaa 270–398UCSCMCM OB domain

MCMaa 445–670UCSCMCM P-loop domain

MCM_lidaa 685–769UCSCMCM AAA-lid domain

WHD_MCM4aa 792–862UCSCMCM4, winged helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 4

HGNC Previous Symbol

CDC21

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_182746.3

p.T366A

c.1096A>G

Surrounding Variants

2 papers

NM_182746.3

p.T366I

c.1097C>T

4 papers

NM_182746.3

p.G364R

c.1090G>A

4 papers

NM_182746.3

p.G364R

c.1090G>C

1 paper

NM_182746.3

p.P362S

c.1084C>T

1 paper

NM_182746.3

p.S357A

c.1069T>G

1 paper

NM_182746.3

p.V379I

c.1135G>A

1 paper

NM_182746.3

p.V379insFs

c.1136_1137insC

4 papers

NM_182746.3

p.F346I

c.1036T>A

1 paper

NM_182746.3

p.H341Y

c.1021C>T

1 paper

NM_182746.3

p.R330H

c.989G>A

1 paper

NM_182746.3

p.C328fs

c.982_983fs

1 paper

NM_182746.3

p.C328delFs

c.982_983delTG