Varaico: Literature-Extracted Genetic Variants

MCM4

185 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 163–264UCSCMCM N-terminal domain

MCM_OBaa 270–398UCSCMCM OB domain

MCMaa 445–670UCSCMCM P-loop domain

MCM_lidaa 685–769UCSCMCM AAA-lid domain

WHD_MCM4aa 792–862UCSCMCM4, winged helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 4

HGNC Previous Symbol

CDC21

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_182746.3

p.D577N

c.1729G>A

Surrounding Variants

1 paper

NM_182746.3

p.D577_T583delFs

c.1731_1747del17

1 paper

NM_182746.3

p.S582T

c.1745G>C

1 paper

NM_182746.3

p.C571F

c.1712G>T

1 paper

NM_182746.3

p.E592K

c.1774G>A

1 paper

NM_182746.3

p.R554W

c.1660A>T

1 paper

NM_182746.3

p.E552K

c.1654G>A

1 paper

NM_182746.3

p.A545V

c.1634C>T

1 paper

NM_182746.3

p.A540T

c.1618G>A

1 paper

NM_182746.3

p.V527I

c.1579G>A

1 paper

NM_182746.3

p.D511N

c.1531G>A

1 paper

NM_182746.3

p.K499R

c.1496A>G

1 paper

NM_182746.3

p.S493delFs

c.1477delA