Varaico: Literature-Extracted Genetic Variants

MCM4

185 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 163–264UCSCMCM N-terminal domain

MCM_OBaa 270–398UCSCMCM OB domain

MCMaa 445–670UCSCMCM P-loop domain

MCM_lidaa 685–769UCSCMCM AAA-lid domain

WHD_MCM4aa 792–862UCSCMCM4, winged helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 4

HGNC Previous Symbol

CDC21

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_182746.3

p.R610H

c.1829G>A

Surrounding Variants

1 paper

NM_182746.3

p.R610C

c.1828C>T

1 paper

NM_182746.3

p.Q606R

c.1817A>G

1 paper

NM_182746.3

p.N618D

c.1852A>G

1 paper

NM_182746.3

p.E621Q

c.1861G>C

1 paper

NM_182746.3

p.Q623*

c.1867C>T

1 paper

NM_182746.3

p.Q623R

c.1868A>G

1 paper

NM_182746.3

p.L640S

c.1919T>C

1 paper

NM_182746.3

p.E592K

c.1774G>A

1 paper

NM_182746.3

p.S582T

c.1745G>C

1 paper

NM_182746.3

p.D577N

c.1729G>A

1 paper

NM_182746.3

p.D577_T583delFs

c.1731_1747del17

1 paper

NM_182746.3

p.C571F

c.1712G>T