Varaico: Literature-Extracted Genetic Variants

MCM4

185 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 163–264UCSCMCM N-terminal domain

MCM_OBaa 270–398UCSCMCM OB domain

MCMaa 445–670UCSCMCM P-loop domain

MCM_lidaa 685–769UCSCMCM AAA-lid domain

WHD_MCM4aa 792–862UCSCMCM4, winged helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 4

HGNC Previous Symbol

CDC21

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_182746.3

p.R660S

c.1980G>C

Surrounding Variants

1 paper

NM_182746.3

p.R660S

c.1980G>T

1 paper

NM_182746.3

p.A657V

c.1970C>T

7 papers

NM_182746.3

p.L650M

c.1948T>A

1 paper

NM_182746.3

p.L649H

c.1946T>A

1 paper

NM_182746.3

p.L649R

c.1946T>G

2 papers

NM_182746.3

p.M684insFs

c.2050dupA

2 papers

NM_182746.3

p.D683E

c.2049C>G

1 paper

NM_182746.3

p.M684I

c.2052G>C

1 paper

NM_182746.3

p.K688R

c.2063A>G

1 paper

NM_182746.3

p.A694T

c.2080G>A

2 papers

NM_182746.3

p.T697insFs

c.2091dupC

1 paper

NM_182746.3

p.T697I

c.2090C>T