Varaico: Literature-Extracted Genetic Variants

MCM6

149 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 27–116UCSCMCM N-terminal domain

MCM_OBaa 122–252UCSCMCM OB domain

MCMaa 333–556UCSCMCM P-loop domain

MCM_lidaa 570–656UCSCMCM AAA-lid domain

WHD_MCM6aa 711–819UCSCMCM6 C-terminal winged-helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 6

HGNC Alias Symbol

Mis5

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005915.6

p.R602H

c.1805G>A

Surrounding Variants

1 paper

NM_005915.6

p.D605G

c.1814A>G

1 paper

NM_005915.6

p.V609L

c.1825G>T

1 paper

NM_005915.6

p.Q620Q

c.1860G>A

1 paper

NM_005915.6

p.M631V

c.1891A>G

1 paper

NM_005915.6

p.R633W

c.1897C>T

1 paper

NM_005915.6

p.R633P

c.1898G>C

1 paper

NM_005915.6

p.R633Q

c.1898G>A

1 paper

NM_005915.6

p.E639_V640Splc

c.1917+225C>T

7 papers

NM_005915.6

p.E639_V640Splc

c.1917+326C>T

1 paper

NM_005915.6

p.R565C

c.1693C>T

1 paper

NM_005915.6

p.I563I

c.1689T>C

1 paper

NM_005915.6

p.H556Y

c.1666C>T