Varaico: Literature-Extracted Genetic Variants

MCM6

149 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 27–116UCSCMCM N-terminal domain

MCM_OBaa 122–252UCSCMCM OB domain

MCMaa 333–556UCSCMCM P-loop domain

MCM_lidaa 570–656UCSCMCM AAA-lid domain

WHD_MCM6aa 711–819UCSCMCM6 C-terminal winged-helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 6

HGNC Alias Symbol

Mis5

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005915.6

p.I482V

c.1444A>G

Surrounding Variants

1 paper

NM_005915.6

p.I473N

c.1418T>A

1 paper

NM_005915.6

p.A472S

c.1414G>T

1 paper

NM_005915.6

p.Q470R

c.1409A>G

1 paper

NM_005915.6

p.R468W

c.1402C>T

1 paper

NM_005915.6

p.D463G

c.1388A>G

1 paper

NM_005915.6

p.V456M

c.1366G>A

2 papers

NM_005915.6

p.A495T

c.1483G>A

1 paper

NM_005915.6

p.S507G

c.1519A>G

1 paper

NM_005915.6

p.P525S

c.1573C>T

1 paper

NM_005915.6

p.I526I

c.1578C>T

1 paper

NM_005915.6

p.L449F

c.1347G>T

1 paper

NM_005915.6

p.L449F

c.1347G>C