Varaico: Literature-Extracted Genetic Variants

MCM6

149 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 27–116UCSCMCM N-terminal domain

MCM_OBaa 122–252UCSCMCM OB domain

MCMaa 333–556UCSCMCM P-loop domain

MCM_lidaa 570–656UCSCMCM AAA-lid domain

WHD_MCM6aa 711–819UCSCMCM6 C-terminal winged-helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 6

HGNC Alias Symbol

Mis5

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005915.6

p.I444M

c.1332T>G

Surrounding Variants

1 paper

NM_005915.6

p.H440Q

c.1320T>G

1 paper

NM_005915.6

p.H440Q

c.1320T>A

1 paper

NM_005915.6

p.H440Y

c.1318C>T

1 paper

NM_005915.6

p.L449F

c.1347G>T

1 paper

NM_005915.6

p.L449F

c.1347G>C

1 paper

NM_005915.6

p.E438G

c.1313A>G

1 paper

NM_005915.6

p.S425I

c.1274G>T

1 paper

NM_005915.6

p.V409M

c.1225G>A

1 paper

NM_005915.6

p.H408Y

c.1222C>T

1 paper

NM_005915.6

p.V456M

c.1366G>A

1 paper

NM_005915.6

p.D463G

c.1388A>G

1 paper

NM_005915.6

p.R468W

c.1402C>T