Varaico: Literature-Extracted Genetic Variants

MCM6

149 papers

RefSeq Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein...

Pfam Domains

MCM_Naa 27–116UCSCMCM N-terminal domain

MCM_OBaa 122–252UCSCMCM OB domain

MCMaa 333–556UCSCMCM P-loop domain

MCM_lidaa 570–656UCSCMCM AAA-lid domain

WHD_MCM6aa 711–819UCSCMCM6 C-terminal winged-helix domain

Gene Aliases

HGNC Name

minichromosome maintenance complex component 6

HGNC Alias Symbol

Mis5

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005915.6

p.A304V

c.911C>T

Surrounding Variants

2 papers

NM_005915.6

p.P305S

c.913C>T

1 paper

NM_005915.6

p.V303I

c.907G>A

1 paper

NM_005915.6

p.T306I

c.917C>T

1 paper

NM_005915.6

p.L284F

c.850C>T

1 paper

NM_005915.6

p.R269H

c.806G>A

1 paper

NM_005915.6

p.T266T

c.798T>A

1 paper

NM_005915.6

p.R263H

c.788G>A

1 paper

NM_005915.6

p.G261E

c.782G>A

1 paper

NM_005915.6

p.G261Splc

c.782-2A>G

1 paper

NM_005915.6

p.T259I

c.776C>T

1 paper

NM_005915.6

p.T259K

c.776C>A

1 paper

NM_005915.6

p.V250I

c.748G>A