Varaico: Literature-Extracted Genetic Variants

MDM4

428 papers

RefSeq Summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both p...

Pfam Domains

SWIBaa 25–95UCSCSWIB/MDM2 domain

Zn_ribbon_RanBPaa 202–231UCSCZn-finger in Ran binding protein and others

Zn_ribbon_RanBPaa 300–329UCSCZn-finger in Ran binding protein and others

zf-C3HC4_3aa 336–386UCSCZinc finger, C3HC4 type (RING finger)

Gene Aliases

HGNC Name

MDM4 regulator of p53

HGNC Alias Symbols

MDMX; HDMX

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002393.5

p.D153H

c.457G>C

Surrounding Variants

6 papers

NM_002393.5

p.D153G

c.458A>G

1 paper

NM_002393.5

p.D154N

c.460G>A

1 paper

NM_002393.5

p.T151P

c.451A>C

1 paper

NM_002393.5

p.R149K

c.446G>A

1 paper

NM_002393.5

p.L158P

c.473T>C

1 paper

NM_002393.5

p.P159S

c.475C>T

1 paper

NM_002393.5

p.P159H

c.476C>A

1 paper

NM_002393.5

p.S146S

c.438C>G

1 paper

NM_002393.5

p.S146Y

c.437C>A

1 paper

NM_002393.5

p.S146C

c.437C>G

2 papers

NM_002393.5

p.T160S

c.478A>T

2 papers

NM_002393.5

p.T160S

c.479C>G