Varaico: Literature-Extracted Genetic Variants

Gene:ME3
Variant:p.G495R

ME3

51 papers

RefSeq Summary

Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-...

Pfam Domains

malicaa 114–295UCSCMalic enzyme, N-terminal domain
Malic_Maa 305–557UCSCMalic enzyme, NAD binding domain

Gene Aliases

HGNC Name

malic enzyme 3

HGNC Previous Name

malic enzyme 3, NADP(+)-dependent, mitochondrial

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_001161586.3
p.G495R
c.1483G>C
Surrounding Variants
2 papers
NM_001161586.3
p.G495R
c.1483G>A
1 paper
NM_001161586.3
p.F493I
c.1477T>A
1 paper
NM_001161586.3
p.G479S
c.1435G>A
1 paper
NM_001161586.3
p.R462*
c.1384C>T
1 paper
NM_001161586.3
p.R457W
c.1369C>T
2 papers
NM_001161586.3
p.A418T
c.1252G>A
1 paper
NM_001161586.3
p.V406E
c.1217T>A
1 paper
NM_001161586.3
p.E401K
c.1201G>A
1 paper
NM_001161586.3
p.S539N
c.1616G>A
2 papers
NM_001161586.3
p.V544A
c.1631T>C
1 paper
NM_001161586.3
p.E353E
c.1059G>A
2 papers
NM_001161586.3
p.K324N
c.972G>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."