mediator complex subunit 26

CRSP7

CRSP70

cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa

Mediator of RNA polymerase II transcription subunit 26

Activator-recruited cofactor 70 kDa component

Cofactor required for Sp1 transcriptional activation subunit 7

Mediator complex subunit 26

Transcriptional coactivator CRSP70

ARC70

CRSP complex subunit 7

Mediator complex subunit 26 middle domain

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

MED26

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol