Varaico: Literature-Extracted Genetic Variants

Gene:MET

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain
PSIaa 519–562UCSCPlexin repeat
TIGaa 563–654UCSCIPT/TIG domain
TIGaa 657–739UCSCIPT/TIG domain
TIGaa 742–830UCSCIPT/TIG domain
PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers
RefSeq ID
Protein change
DNA change
1–12 of 3339 variants
324 papers
NM_000245.4
p.L858R
c.2573T>G
191 papers
NM_000245.4
p.N375S
c.1124A>G
110 papers
NM_000245.4
p.D1228N
c.3682G>A
107 papers
NM_000245.4
p.Y1230C
c.3689A>G
106 papers
NM_000245.4
p.M1250T
c.3749T>C
105 papers
NM_000245.4
p.E168D
c.504G>T
101 papers
NM_000245.4
p.E168D
c.504G>C
94 papers
NM_000245.4
p.Y1235D
c.3703T>G
93 papers
NM_000245.4
p.Y1230H
c.3688T>C
81 papers
NM_000245.4
p.D1228H
c.3682G>C
74 papers
NM_000245.4
p.T992I
c.2975C>T
62 papers
NM_000245.4
p.D1010H
c.3028G>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."