Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000245.4

p.E76K

c.226G>A

Surrounding Variants

1 paper

NM_000245.4

p.E76fs

c.226_227fs

1 paper

NM_000245.4

p.E76A

c.227A>C

1 paper

NM_000245.4

p.E76G

c.227A>G

2 papers

NM_000245.4

p.E75A

c.224A>C

1 paper

NM_000245.4

p.E75K

c.223G>A

1 paper

NM_000245.4

p.L78F

c.232C>T

1 paper

NM_000245.4

p.L78H

c.233T>A

2 papers

NM_000245.4

p.L73*

c.218T>A

2 papers

NM_000245.4

p.L73*

c.218T>G

2 papers

NM_000245.4

p.Q79delFs

c.235delC

1 paper

NM_000245.4

p.Q79K

c.235C>A

1 paper

NM_000245.4

p.Q79*

c.235C>T