Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.V176L

c.526G>T

Surrounding Variants

2 papers

NM_000245.4

p.V176M

c.526G>A

1 paper

NM_000245.4

p.V176L

c.526G>C

3 papers

NM_000245.4

p.C175*

c.525T>A

1 paper

NM_000245.4

p.V176E

c.527T>A

2 papers

NM_000245.4

p.C175Y

c.524G>A

1 paper

NM_000245.4

p.C175fs

c.523_524fs

2 papers

NM_000245.4

p.V177G

c.530T>G

1 paper

NM_000245.4

p.S178R

c.532A>C

1 paper

NM_000245.4

p.S178_A182delFs

c.533_546del14

1 paper

NM_000245.4

p.D174N

c.520G>A

1 paper

NM_000245.4

p.S178N

c.533G>A

6 papers

NM_000245.4

p.S178T

c.533G>C