Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.L219fs

c.655_656fs

Surrounding Variants

1 paper

NM_000245.4

p.L219I

c.655C>A

1 paper

NM_000245.4

p.R218R

c.654G>A

2 papers

NM_000245.4

p.R218S

c.654G>C

2 papers

NM_000245.4

p.R218S

c.654G>T

1 paper

NM_000245.4

p.K220del1

c.658_660delAAG

2 papers

NM_000245.4

p.K220R

c.659A>G

1 paper

NM_000245.4

p.K220K

c.660G>A

1 paper

NM_000245.4

p.R217I

c.650G>T

1 paper

NM_000245.4

p.E221K

c.661G>A

4 papers

NM_000245.4

p.E221G

c.662A>G

1 paper

NM_000245.4

p.R217del1

c.649_650delAGA

1 paper

NM_000245.4

p.E221E

c.663A>G