Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.D224G

c.671A>G

Surrounding Variants

1 paper

NM_000245.4

p.D224A

c.671A>C

1 paper

NM_000245.4

p.D224Y

c.670G>T

1 paper

NM_000245.4

p.K223K

c.669A>G

1 paper

NM_000245.4

p.K223N

c.669A>T

1 paper

NM_000245.4

p.G225S

c.673G>A

4 papers

NM_000245.4

p.G225D

c.674G>A

1 paper

NM_000245.4

p.G225G

c.675T>C

2 papers

NM_000245.4

p.T222T

c.666G>A

1 paper

NM_000245.4

p.F226L

c.676T>C

1 paper

NM_000245.4

p.F226_D231delFs

c.677_693del17

2 papers

NM_000245.4

p.T222K

c.665C>A

3 papers

NM_000245.4

p.T222M

c.665C>T