Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.I247_F253del7

c.739_758del21

Surrounding Variants

1 paper

NM_000245.4

p.P246P

c.738C>T

4 papers

NM_000245.4

p.I247V

c.739A>G

5 papers

NM_000245.4

p.P246L

c.737C>T

1 paper

NM_000245.4

p.P246T

c.736C>A

2 papers

NM_000245.4

p.P246S

c.736C>T

1 paper

NM_000245.4

p.K248M

c.743A>T

1 paper

NM_000245.4

p.Y245H

c.733T>C

2 papers

NM_000245.4

p.K248N

c.744G>C

2 papers

NM_000245.4

p.K248N

c.744G>T

1 paper

NM_000245.4

p.Y249_V250del0

c.745_750del6

1 paper

NM_000245.4

p.S244S

c.732T>C

2 papers

NM_000245.4

p.S244F

c.731C>T