Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000245.4

p.R280S

c.840G>T

Surrounding Variants

4 papers

NM_000245.4

p.R280S

c.840G>C

3 papers

NM_000245.4

p.R280K

c.839G>A

4 papers

NM_000245.4

p.R280T

c.839G>C

1 paper

NM_000245.4

p.F281V

c.841T>G

3 papers

NM_000245.4

p.R280G

c.838A>G

1 paper

NM_000245.4

p.C282Y

c.845G>A

1 paper

NM_000245.4

p.C282F

c.845G>T

1 paper

NM_000245.4

p.S283T

c.847T>A

1 paper

NM_000245.4

p.I278T

c.833T>C

1 paper

NM_000245.4

p.S283Y

c.848C>A

2 papers

NM_000245.4

p.S283S

c.849C>T

1 paper

NM_000245.4

p.I284fs

c.850_851fs