Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000245.4

p.L288M

c.862T>A

Surrounding Variants

1 paper

NM_000245.4

p.G287G

c.861A>C

1 paper

NM_000245.4

p.S290delFs

c.868delT

1 paper

NM_000245.4

p.S286S

c.858T>G

1 paper

NM_000245.4

p.S286C

c.857C>G

1 paper

NM_000245.4

p.S290P

c.868T>C

1 paper

NM_000245.4

p.N285D

c.853A>G

3 papers

NM_000245.4

p.I284M

c.852A>G

1 paper

NM_000245.4

p.Y291F

c.872A>T

1 paper

NM_000245.4

p.Y291*

c.873C>A

1 paper

NM_000245.4

p.Y291*

c.873C>G

1 paper

NM_000245.4

p.I284T

c.851T>C

1 paper

NM_000245.4

p.I284fs

c.850_851fs