Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.E312D

c.936A>T

Surrounding Variants

1 paper

NM_000245.4

p.V313L

c.937G>T

1 paper

NM_000245.4

p.E312K

c.934G>A

1 paper

NM_000245.4

p.F314L

c.940T>C

1 paper

NM_000245.4

p.F314L

c.942T>A

1 paper

NM_000245.4

p.F314L

c.942T>G

3 papers

NM_000245.4

p.N315S

c.944A>G

1 paper

NM_000245.4

p.T309I

c.926C>T

4 papers

NM_000245.4

p.I316M

c.948A>G

2 papers

NM_000245.4

p.L317I

c.949C>A

2 papers

NM_000245.4

p.L317P

c.950T>C

1 paper

NM_000245.4

p.Q318K

c.952C>A

1 paper

NM_000245.4

p.Q318*

c.952C>T