Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.G334R

c.1000G>A

Surrounding Variants

1 paper

NM_000245.4

p.G334R

c.1000G>C

1 paper

NM_000245.4

p.G334E

c.1001G>A

1 paper

NM_000245.4

p.I333T

c.998T>C

3 papers

NM_000245.4

p.I333L

c.997A>C

3 papers

NM_000245.4

p.I333L

c.997A>T

1 paper

NM_000245.4

p.A335Fs

c.1003delinsGAFs

1 paper

NM_000245.4

p.A335D

c.1004C>A

1 paper

NM_000245.4

p.Q332K

c.994C>A

1 paper

NM_000245.4

p.S336S

c.1008C>T

1 paper

NM_000245.4

p.R331T

c.992G>C

3 papers

NM_000245.4

p.L337Q

c.1010T>A

1 paper

NM_000245.4

p.L329fs

c.985_986fs