Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.D352fs

c.1054_1055fs

Surrounding Variants

1 paper

NM_000245.4

p.D352Y

c.1054G>T

1 paper

NM_000245.4

p.P351L

c.1052C>T

1 paper

NM_000245.4

p.P351T

c.1051C>A

1 paper

NM_000245.4

p.P351S

c.1051C>T

3 papers

NM_000245.4

p.S353F

c.1058C>T

1 paper

NM_000245.4

p.K350N

c.1050G>C

1 paper

NM_000245.4

p.K350N

c.1050G>T

1 paper

NM_000245.4

p.K350T

c.1049A>C

1 paper

NM_000245.4

p.K350Q

c.1048A>C

1 paper

NM_000245.4

p.A354D

c.1061C>A

1 paper

NM_000245.4

p.A354V

c.1061C>T

3 papers

NM_000245.4

p.S349G

c.1045A>G