Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.Y835C

c.2504A>G

Surrounding Variants

1 paper

NM_000245.4

p.Y835F

c.2504A>T

1 paper

NM_000245.4

p.I834M

c.2502T>G

1 paper

NM_000245.4

p.V836_H837ins1

c.2508_2509insGAA

1 paper

NM_000245.4

p.V836V

c.2508A>G

1 paper

NM_001127500.3

p.I852F

c.2554A>T

1 paper

NM_000245.4

p.L833L

c.2499C>G

1 paper

NM_000245.4

p.L833fs

c.2497_2498fs

6 papers

NM_000245.4

p.L833V

c.2497C>G

2 papers

NM_000245.4

p.L833F

c.2497C>T

1 paper

NM_000245.4

p.H837Q

c.2511T>A

1 paper

NM_000245.4

p.L833insFs

c.2497dupC

1 paper

NM_000245.4

p.N838T

c.2513A>C