Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.I850V

c.2548A>G

Surrounding Variants

1 paper

NM_000245.4

p.M849I

c.2547G>A

1 paper

NM_000245.4

p.M849I

c.2547G>C

1 paper

NM_000245.4

p.M849I

c.2547G>T

2 papers

NM_000245.4

p.S851*

c.2552C>A

2 papers

NM_000245.4

p.S851*

c.2552C>G

2 papers

NM_000245.4

p.V848A

c.2543T>C

1 paper

NM_000245.4

p.M852L

c.2554A>T

1 paper

NM_000245.4

p.V848M

c.2542G>A

1 paper

NM_000245.4

p.M852K

c.2555T>A

1 paper

NM_000245.4

p.G853C

c.2557G>T

1 paper

NM_000245.4

p.K846R

c.2537A>G

1 paper

NM_000245.4

p.N854fs

c.2560_2561fs