Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.E855*

c.2563G>T

Surrounding Variants

1 paper

NM_000245.4

p.E855G

c.2564A>G

1 paper

NM_000245.4

p.N856insFs

c.2566_2567insAT

1 paper

NM_000245.4

p.N854fs

c.2560_2561fs

1 paper

NM_000245.4

p.N854_N856delFs

c.2561_2568del8

1 paper

NM_000245.4

p.G853C

c.2557G>T

1 paper

NM_000245.4

p.M852K

c.2555T>A

1 paper

NM_000245.4

p.M852L

c.2554A>T

4 papers

NM_000245.4

p.L858M

c.2572C>A

1 paper

NM_000245.4

p.L858V

c.2572C>G

1 paper

NM_000245.4

p.L858Q

c.2573T>A

324 papers

NM_000245.4

p.L858R

c.2573T>G

2 papers

NM_000245.4

p.S851*

c.2552C>A