Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

324 papers

NM_000245.4

p.L858R

c.2573T>G

Surrounding Variants

1 paper

NM_000245.4

p.L858Q

c.2573T>A

4 papers

NM_000245.4

p.L858M

c.2572C>A

1 paper

NM_000245.4

p.L858V

c.2572C>G

1 paper

NM_000245.4

p.L858L

c.2574G>T

1 paper

NM_000245.4

p.E859G

c.2576A>G

1 paper

NM_000245.4

p.I860S

c.2579T>G

1 paper

NM_000245.4

p.N856insFs

c.2566_2567insAT

2 papers

NM_000245.4

p.K861R

c.2582A>G

1 paper

NM_000245.4

p.E855G

c.2564A>G

1 paper

NM_000245.4

p.K861N

c.2583G>C

1 paper

NM_000245.4

p.E855*

c.2563G>T

1 paper

NM_000245.4

p.K861N

c.2583G>T