Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001127500.3

p.V993_A1004del0

c.2978_3010del33

Surrounding Variants

1 paper

NM_000245.4

p.R974K

c.2921G>A

1 paper

NM_000245.4

p.R974T

c.2921G>C

1 paper

NM_001127500.3

p.R992_V993delins

c.2975_2978delinsATAA

1 paper

NM_000245.4

p.H976D

c.2926C>G

1 paper

NM_000245.4

p.A973V

c.2918C>T

1 paper

NM_001127500.3

p.T995_T1010delFs

c.2983_3028del46

1 paper

NM_000245.4

p.D972D

c.2916T>C

2 papers

NM_000245.4

p.T977A

c.2929A>G

1 paper

NM_000245.4

p.T977_P978del1

c.2930_2932delCTC

3 papers

NM_000245.4

p.D972N

c.2914G>A

1 paper

NM_000245.4

p.D972H

c.2914G>C

1 paper

NM_000245.4

p.D972Y

c.2914G>T