Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.D981delFs

c.2942delA

Surrounding Variants

1 paper

NM_001127500.3

p.D999Y

c.2995G>T

1 paper

NM_000245.4

p.D981fs

c.2941_2942fs

1 paper

NM_000245.4

p.D981_L983delFs

c.2942_2949del8

1 paper

NM_000245.4

p.D981V

c.2942A>T

1 paper

NM_000245.4

p.L980_V984insFs

c.2940_2952dup13

1 paper

NM_000245.4

p.R982M

c.2945G>T

1 paper

NM_001127500.3

p.H997R

c.2990A>G

NM_000245.4

p.H979R

c.2936A>G

1 paper

NM_000245.4

p.R982S

c.2946G>C

2 papers

NM_000245.4

p.R982S

c.2946G>T

1 paper

NM_001127500.3

p.L1001_V1007del0

c.3001_3021del21

1 paper

NM_001127500.3

p.L1001_T1010delFs

c.3001_3028del28

1 paper

NM_000245.4

p.L983I

c.2947C>A