Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_001127500.3

p.L1130S

c.3389T>C

NM_000245.4

p.L1112S

c.3335T>C

Surrounding Variants

2 papers

NM_000245.4

p.L1112F

c.3336G>C

2 papers

NM_000245.4

p.L1112F

c.3336G>T

2 papers

NM_000245.4

p.N1113S

c.3338A>G

1 paper

NM_000245.4

p.N1113I

c.3338A>T

1 paper

NM_000245.4

p.S1111Y

c.3332C>A

1 paper

NM_000245.4

p.S1111C

c.3332C>G

2 papers

NM_000245.4

p.S1111F

c.3332C>T

1 paper

NM_000245.4

p.N1113K

c.3339C>A

1 paper

NM_000245.4

p.N1113K

c.3339C>G

1 paper

NM_000245.4

p.S1111T

c.3331T>A

1 paper

NM_000245.4

p.K1110N

c.3330A>C

2 papers

NM_001127500.3

p.R1132G

c.3394A>G