Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000245.4

p.I1130del1

c.3388_3389delATC

Surrounding Variants

1 paper

NM_000245.4

p.G1128E

c.3383G>A

5 papers

NM_000245.4

p.G1128A

c.3383G>C

1 paper

NM_000245.4

p.G1128R

c.3382G>A

1 paper

NM_000245.4

p.G1128R

c.3382G>C

1 paper

NM_000245.4

p.I1129N

c.3386T>A

1 paper

NM_000245.4

p.E1127D

c.3381G>C

1 paper

NM_000245.4

p.E1127D

c.3381G>T

1 paper

NM_000245.4

p.E1127G

c.3380A>G

2 papers

NM_000245.4

p.E1127K

c.3379G>A

1 paper

NM_000245.4

p.E1127Q

c.3379G>C

1 paper

NM_000245.4

p.E1127*

c.3379G>T

2 papers

NM_000245.4

p.I1130T

c.3389T>C