Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.L1140V

c.3418C>G

Surrounding Variants

2 papers

NM_000245.4

p.L1140F

c.3418C>T

1 paper

NM_000245.4

p.V1139A

c.3416T>C

1 paper

NM_000245.4

p.V1139G

c.3416T>G

2 papers

NM_000245.4

p.V1139I

c.3415G>A

1 paper

NM_000245.4

p.V1139F

c.3415G>T

2 papers

NM_000245.4

p.S1141W

c.3422C>G

NM_001127500.3

p.S1159W

c.3476C>G

2 papers

NM_000245.4

p.S1141L

c.3422C>T

2 papers

NM_000245.4

p.N1138K

c.3414T>A

2 papers

NM_000245.4

p.N1138K

c.3414T>G

1 paper

NM_000245.4

p.N1138S

c.3413A>G

1 paper

NM_000245.4

p.N1138I

c.3413A>T

1 paper

NM_000245.4

p.N1138D

c.3412A>G