Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000245.4

p.L1147M

c.3439C>A

Surrounding Variants

1 paper

NM_000245.4

p.C1146W

c.3438C>G

1 paper

NM_000245.4

p.L1147P

c.3440T>C

1 paper

NM_000245.4

p.C1146Y

c.3437G>A

1 paper

NM_000245.4

p.C1146F

c.3437G>T

3 papers

NM_000245.4

p.R1148*

c.3442C>T

1 paper

NM_000245.4

p.I1145M

c.3435C>G

7 papers

NM_000245.4

p.R1148Q

c.3443G>A

2 papers

NM_000245.4

p.R1148L

c.3443G>T

1 paper

NM_000245.4

p.I1145N

c.3434T>A

1 paper

NM_000245.4

p.S1149R

c.3445A>C

1 paper

NM_000245.4

p.I1145V

c.3433A>G

2 papers

NM_000245.4

p.S1149N

c.3446G>A