Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

41 papers

NM_000245.4

p.G1163R

c.3487G>C

NM_001127500.3

p.G1181R

c.3541G>C

Surrounding Variants

41 papers

NM_000245.4

p.G1163R

c.3487G>A

NM_001127500.3

p.G1181R

c.3541G>A

1 paper

NM_000245.4

p.G1163*

c.3487G>T

4 papers

NM_000245.4

p.G1163E

c.3488G>A

1 paper

NM_000245.4

p.G1163A

c.3488G>C

2 papers

NM_000245.4

p.G1163V

c.3488G>T

2 papers

NM_000245.4

p.H1162R

c.3485A>G

1 paper

NM_000245.4

p.H1162L

c.3485A>T

2 papers

NM_000245.4

p.H1162N

c.3484C>A

1 paper

NM_001127500.3

p.H1180Y

c.3538C>T

NM_000245.4

p.H1162Y

c.3484C>T

1 paper

NM_000245.4

p.D1164N

c.3490G>A

2 papers

NM_000245.4

p.D1164H

c.3490G>C

2 papers

NM_000245.4

p.D1164Y

c.3490G>T