Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

82 papers

NM_000245.4

p.D1228H

c.3682G>C

NM_001127500.3

p.D1246H

c.3736G>C

Surrounding Variants

114 papers

NM_000245.4

p.D1228N

c.3682G>A

NM_001127500.3

p.D1246N

c.3736G>A

14 papers

NM_000245.4

p.D1228Y

c.3682G>T

10 papers

NM_000245.4

p.D1228A

c.3683A>C

1 paper

NM_000245.4

p.R1227S

c.3681A>C

5 papers

NM_000245.4

p.D1228G

c.3683A>G

48 papers

NM_000245.4

p.D1228V

c.3683A>T

NM_001127500.3

p.D1246V

c.3737A>T

1 paper

NM_000245.4

p.R1227S

c.3681A>T

6 papers

NM_000245.4

p.D1228E

c.3684C>A

6 papers

NM_000245.4

p.D1228E

c.3684C>G

3 papers

NM_000245.4

p.R1227K

c.3680G>A

1 paper

NM_000245.4

p.R1227T

c.3680G>C

1 paper

NM_000245.4

p.R1227I

c.3680G>T