Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000245.4

p.Y1235H

c.3703T>C

Surrounding Variants

97 papers

NM_000245.4

p.Y1235D

c.3703T>G

NM_001127500.3

p.Y1253D

c.3757T>G

3 papers

NM_000245.4

p.Y1235C

c.3704A>G

3 papers

NM_000245.4

p.Y1235F

c.3704A>T

1 paper

NM_000245.4

p.Y1234*

c.3702C>A

1 paper

NM_000245.4

p.Y1234*

c.3702C>G

4 papers

NM_000245.4

p.Y1234C

c.3701A>G

10 papers

NM_000245.4

p.Y1234F

c.3701A>T

3 papers

NM_000245.4

p.S1236R

c.3706A>C

1 paper

NM_000245.4

p.S1236G

c.3706A>G

1 paper

NM_000245.4

p.S1236C

c.3706A>T

1 paper

NM_000245.4

p.Y1234H

c.3700T>C

1 paper

NM_000245.4

p.Y1234D

c.3700T>G