Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.W1249_M1250del1

c.3747_3749delGAT

Surrounding Variants

3 papers

NM_000245.4

p.W1249*

c.3746G>A

3 papers

NM_000245.4

p.W1249*

c.3747G>A

1 paper

NM_000245.4

p.W1249C

c.3747G>C

1 paper

NM_000245.4

p.W1249C

c.3747G>T

1 paper

NM_000245.4

p.W1249R

c.3745T>A

1 paper

NM_000245.4

p.W1249R

c.3745T>C

1 paper

NM_000245.4

p.K1248N

c.3744G>C

1 paper

NM_000245.4

p.K1248N

c.3744G>T

1 paper

NM_000245.4

p.K1248T

c.3743A>C

13 papers

NM_000245.4

p.K1248R

c.3743A>G

112 papers

NM_000245.4

p.M1250T

c.3749T>C

NM_001127500.3

p.M1268T

c.3803T>C

3 papers

NM_000245.4

p.M1250I

c.3750G>A