Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001127500.3

p.Q1274P

c.3821A>C

Surrounding Variants

1 paper

NM_000245.4

p.Q1256R

c.3767A>G

1 paper

NM_000245.4

p.Q1256L

c.3767A>T

1 paper

NM_000245.4

p.Q1256K

c.3766C>A

1 paper

NM_000245.4

p.T1257P

c.3769A>C

3 papers

NM_001127500.3

p.T1275S

c.3823A>T

NM_000245.4

p.T1257S

c.3769A>T

3 papers

NM_001127500.3

p.T1275S

c.3824C>G

NM_000245.4

p.T1257S

c.3770C>G

1 paper

NM_001127500.3

p.T1275I

c.3824C>T

1 paper

NM_000245.4

p.L1255P

c.3764T>C

1 paper

NM_000245.4

p.L1255M

c.3763C>A

2 papers

NM_001127500.3

p.L1273V

c.3817C>G

NM_000245.4

p.L1255V

c.3763C>G

2 papers

NM_000245.4

p.Q1258K

c.3772C>A

1 paper

NM_000245.4

p.Q1258E

c.3772C>G