Varaico: Literature-Extracted Genetic Variants

MGMT

604 papers

RefSeq Summary

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutag...

Pfam Domains

Methyltransf_1Naa 7–83UCSC6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

DNA_binding_1aa 93–174UCSC6-O-methylguanine DNA methyltransferase, DNA binding domain

Gene Aliases

HGNC Name

O-6-methylguanine-DNA methyltransferase

HGNC Alias Name

methylated-DNA--protein-cysteine methyltransferase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002412.5

p.L33F

c.97C>T

Surrounding Variants

1 paper

NM_002412.5

p.K32K

c.96G>A

2 papers

NM_002412.5

p.L33P

c.98T>C

38 papers

NM_002412.5

p.L33R

c.98T>G

1 paper

NM_002412.5

p.E30K

c.88G>A

1 paper

NM_002412.5

p.L28L

c.84G>A

1 paper

NM_002412.5

p.G27C

c.79G>T

1 paper

NM_002412.5

p.S39C

c.116C>G

1 paper

NM_002412.5

p.G23D

c.68G>A

1 paper

NM_002412.5

p.L21L

c.61C>T

1 paper

NM_002412.5

p.L19L

c.55C>T

1 paper

NM_002412.5

p.P15S

c.43C>T

2 papers

NM_002412.5

p.T11T

c.33A>G