Varaico: Literature-Extracted Genetic Variants

MGMT

604 papers

RefSeq Summary

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutag...

Pfam Domains

Methyltransf_1Naa 7–83UCSC6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

DNA_binding_1aa 93–174UCSC6-O-methylguanine DNA methyltransferase, DNA binding domain

Gene Aliases

HGNC Name

O-6-methylguanine-DNA methyltransferase

HGNC Alias Name

methylated-DNA--protein-cysteine methyltransferase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

15 papers

NM_002412.5

p.W65C

c.195G>C

Surrounding Variants

15 papers

NM_002412.5

p.W65C

c.195G>T

1 paper

NM_002412.5

p.L66V

c.196C>G

1 paper

NM_002412.5

p.L66P

c.197T>C

1 paper

NM_002412.5

p.A68T

c.202G>A

1 paper

NM_002412.5

p.C62S

c.184T>A

2 papers

NM_002412.5

p.M60V

c.178A>G

1 paper

NM_002412.5

p.Q72Q

c.216G>A

1 paper

NM_002412.5

p.P58S

c.172C>T

1 paper

NM_002412.5

p.P73P

c.219C>A

1 paper

NM_002412.5

p.E57V

c.170A>T

1 paper

NM_002412.5

p.E74K

c.220G>A

1 paper

NM_002412.5

p.E74A

c.221A>C