Varaico: Literature-Extracted Genetic Variants

MGMT

604 papers

RefSeq Summary

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutag...

Pfam Domains

Methyltransf_1Naa 7–83UCSC6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

DNA_binding_1aa 93–174UCSC6-O-methylguanine DNA methyltransferase, DNA binding domain

Gene Aliases

HGNC Name

O-6-methylguanine-DNA methyltransferase

HGNC Alias Name

methylated-DNA--protein-cysteine methyltransferase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002412.5

p.L102L

c.306G>A

Surrounding Variants

1 paper

NM_002412.5

p.K104E

c.310A>G

1 paper

NM_002412.5

p.K101E

c.301A>G

1 paper

NM_002412.5

p.K101delFs

c.301delA

1 paper

NM_002412.5

p.W100*

c.299G>A

1 paper

NM_002412.5

p.V105F

c.313G>T

1 paper

NM_002412.5

p.V106M

c.316G>A

1 paper

NM_002412.5

p.K107E

c.319A>G

1 paper

NM_002412.5

p.Q97Q

c.291G>A

1 paper

NM_002412.5

p.Q97*

c.289C>T

1 paper

NM_002412.5

p.V111V

c.333G>A

1 paper

NM_002412.5

p.S93L

c.278C>T

1 paper

NM_002412.5

p.E92E

c.276G>A