Varaico: Literature-Extracted Genetic Variants

MGMT

604 papers

RefSeq Summary

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutag...

Pfam Domains

Methyltransf_1Naa 7–83UCSC6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

DNA_binding_1aa 93–174UCSC6-O-methylguanine DNA methyltransferase, DNA binding domain

Gene Aliases

HGNC Name

O-6-methylguanine-DNA methyltransferase

HGNC Alias Name

methylated-DNA--protein-cysteine methyltransferase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002412.5

p.Q115H

c.345G>T

Surrounding Variants

3 papers

NM_002412.5

p.Q116*

c.346C>T

13 papers

NM_002412.5

p.Q115*

c.343C>T

1 paper

NM_002412.5

p.Y114F

c.341A>T

1 paper

NM_002412.5

p.S113F

c.338C>T

1 paper

NM_002412.5

p.S113P

c.337T>C

1 paper

NM_002412.5

p.A118A

c.354A>G

1 paper

NM_002412.5

p.V111V

c.333G>A

2 papers

NM_002412.5

p.A121T

c.361G>A

2 papers

NM_002412.5

p.A121E

c.362C>A

1 paper

NM_002412.5

p.N123K

c.369C>G

1 paper

NM_002412.5

p.K107E

c.319A>G

1 paper

NM_002412.5

p.P124L

c.371C>T