Varaico: Literature-Extracted Genetic Variants

MGMT

604 papers

RefSeq Summary

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutag...

Pfam Domains

Methyltransf_1Naa 7–83UCSC6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

DNA_binding_1aa 93–174UCSC6-O-methylguanine DNA methyltransferase, DNA binding domain

Gene Aliases

HGNC Name

O-6-methylguanine-DNA methyltransferase

HGNC Alias Name

methylated-DNA--protein-cysteine methyltransferase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002412.5

p.S151C

c.451A>T

Surrounding Variants

1 paper

NM_002412.5

p.S151G

c.451A>G

1 paper

NM_002412.5

p.S151N

c.452G>A

1 paper

NM_002412.5

p.C150Y

c.449G>A

1 paper

NM_002412.5

p.S152R

c.454A>C

1 paper

NM_002412.5

p.S152N

c.455G>A

1 paper

NM_002412.5

p.S152T

c.455G>C

1 paper

NM_002412.5

p.S152R

c.456C>A

1 paper

NM_002412.5

p.S152R

c.456C>G

1 paper

NM_002412.5

p.V149I

c.445G>A

1 paper

NM_002412.5

p.G153G

c.459A>G

1 paper

NM_002412.5

p.A154T

c.460G>A

1 paper

NM_002412.5

p.A154S

c.460G>T