Varaico: Literature-Extracted Genetic Variants

MGMT

604 papers

RefSeq Summary

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutag...

Pfam Domains

Methyltransf_1Naa 7–83UCSC6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

DNA_binding_1aa 93–174UCSC6-O-methylguanine DNA methyltransferase, DNA binding domain

Gene Aliases

HGNC Name

O-6-methylguanine-DNA methyltransferase

HGNC Alias Name

methylated-DNA--protein-cysteine methyltransferase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002412.5

p.W191*

c.573G>A

Surrounding Variants

2 papers

NM_002412.5

p.L192F

c.574C>T

1 paper

NM_002412.5

p.W191*

c.572G>A

1 paper

NM_002412.5

p.K193R

c.578A>G

1 paper

NM_002412.5

p.K193N

c.579G>T

1 paper

NM_002412.5

p.G189E

c.566G>A

1 paper

NM_002412.5

p.G194R

c.580G>A

1 paper

NM_002412.5

p.A195T

c.583G>A

1 paper

NM_002412.5

p.G196A

c.587G>C

1 paper

NM_002412.5

p.G186S

c.556G>A

1 paper

NM_002412.5

p.S184G

c.550A>G

1 paper

NM_002412.5

p.G200C

c.598G>T

1 paper

NM_002412.5

p.P179S

c.535C>T