Varaico: Literature-Extracted Genetic Variants

Gene:MPL
Variant:p.A189D

MPL

1,557 papers

RefSeq Summary

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the huma...

Pfam Domains

EpoR_lig-bindaa 25–128UCSCErythropoietin receptor, ligand binding

Gene Aliases

HGNC Name

MPL proto-oncogene, thrombopoietin receptor

HGNC Alias Symbols

CD110; TPOR; THPOR

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_005373.3
p.A189D
c.566C>A
Surrounding Variants
1 paper
NM_005373.3
p.A189P
c.565G>C
1 paper
NM_005373.3
p.I188T
c.563T>C
1 paper
NM_005373.3
p.I188F
c.562A>T
1 paper
NM_005373.3
p.E191_T192del1
c.572_574delAAA
1 paper
NM_005373.3
p.Q186E
c.556C>G
11 papers
NM_005373.3
p.Q186*
c.556C>T
1 paper
NM_005373.3
p.C193S
c.577T>A
3 papers
NM_005373.3
p.C193Y
c.578G>A
1 paper
NM_005373.3
p.C193S
c.578G>C
1 paper
NM_005373.3
p.V184V
c.552C>G
1 paper
NM_005373.3
p.C194Y
c.581G>A
1 paper
NM_005373.3
p.V184insFs
c.551_552insG
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."