Varaico: Literature-Extracted Genetic Variants

Gene:MPL
Variant:p.V495M

MPL

1,557 papers

RefSeq Summary

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the huma...

Pfam Domains

EpoR_lig-bindaa 25–128UCSCErythropoietin receptor, ligand binding

Gene Aliases

HGNC Name

MPL proto-oncogene, thrombopoietin receptor

HGNC Alias Symbols

CD110; TPOR; THPOR

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_005373.3
p.V495M
c.1483G>A
Surrounding Variants
2 papers
NM_005373.3
p.V495A
c.1484T>C
1 paper
NM_005373.3
p.L494W
c.1481T>G
1 paper
NM_005373.3
p.L494V
c.1480T>G
1 paper
NM_005373.3
p.L498_H499ins4
c.1494_1495ins12
4 papers
NM_005373.3
p.S493C
c.1478C>G
1 paper
NM_005373.3
p.S493F
c.1478C>T
2 papers
NM_005373.3
p.A497T
c.1489G>A
2 papers
NM_005373.3
p.S493A
c.1477T>G
1 paper
NM_005373.3
p.I492M
c.1476C>G
1 paper
NM_005373.3
p.I492T
c.1475T>C
2 papers
NM_005373.3
p.I492V
c.1474A>G
1 paper
NM_005373.3
p.I492F
c.1474A>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."