Varaico: Literature-Extracted Genetic Variants

Gene:MPL
Variant:p.L498_H499ins4

MPL

1,557 papers

RefSeq Summary

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the huma...

Pfam Domains

EpoR_lig-bindaa 25–128UCSCErythropoietin receptor, ligand binding

Gene Aliases

HGNC Name

MPL proto-oncogene, thrombopoietin receptor

HGNC Alias Symbols

CD110; TPOR; THPOR

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_005373.3
p.L498_H499ins4
c.1494_1495ins12
Surrounding Variants
2 papers
NM_005373.3
p.A497T
c.1489G>A
2 papers
NM_005373.3
p.V495A
c.1484T>C
1 paper
NM_005373.3
p.V495M
c.1483G>A
2 papers
NM_005373.3
p.L498V
c.1492C>G
1 paper
NM_005373.3
p.L494W
c.1481T>G
1 paper
NM_005373.3
p.L494V
c.1480T>G
3 papers
NM_005373.3
p.H499Y
c.1495C>T
1 paper
NM_005373.3
p.H499delins
c.1495_1496delinsGT
1 paper
NM_005373.3
p.H499fs
c.1495_1496fs
1 paper
NM_005373.3
p.H499_L500Fs
c.1495_1500delinsGTGATCTCCTTGGTFs
3 papers
NM_005373.3
p.H499L
c.1496A>T
4 papers
NM_005373.3
p.S493C
c.1478C>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."