Varaico: Literature-Extracted Genetic Variants

MSH3

1,102 papers

RefSeq Summary

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch ...

Pfam Domains

MutS_Iaa 230–343UCSCMutS domain I

MutS_IIaa 366–523UCSCMutS domain II

MutS_IIIaa 540–838UCSCMutS domain III

MutS_Vaa 892–1094UCSCMutS domain V

Gene Aliases

HGNC Name

mutS homolog 3

HGNC Alias Symbols

DUP; MRP1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002439.5

p.A60_A65del0

c.178_195del18

Surrounding Variants

7 papers

NM_002439.5

p.A58P

c.172G>C

1 paper

NM_002439.5

p.A57A

c.171C>G

4 papers

NM_002439.5

p.A58V

c.173C>T

1 paper

NM_002439.5

p.A58A

c.174A>C

1 paper

NM_002439.5

p.A58_A60delFs

c.172_179del8

9 papers

NM_002439.5

p.A57P

c.169G>C

1 paper

NM_002439.5

p.A57fs

c.169_170fs

1 paper

NM_002439.5

p.A59_P64delFs

c.176_191del16

1 paper

NM_002439.5

p.A59G

c.176C>G

1 paper

NM_002439.5

p.A57delFs

c.169delG

1 paper

NM_002439.5

p.A59_A60insFs

c.177_178ins8

1 paper

NM_002439.5

p.A60ins2

c.178_179ins6