Varaico: Literature-Extracted Genetic Variants

MSH3

1,102 papers

RefSeq Summary

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch ...

Pfam Domains

MutS_Iaa 230–343UCSCMutS domain I

MutS_IIaa 366–523UCSCMutS domain II

MutS_IIIaa 540–838UCSCMutS domain III

MutS_Vaa 892–1094UCSCMutS domain V

Gene Aliases

HGNC Name

mutS homolog 3

HGNC Alias Symbols

DUP; MRP1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

19 papers

NM_002439.5

p.A61_P63ins1

c.181_189dup9

Surrounding Variants

13 papers

NM_002439.5

p.A60P

c.178G>C

1 paper

NM_002439.5

p.P63_P64ins6

c.189_190ins18

6 papers

NM_002439.5

p.A62_P63ins6

c.186_187ins18

1 paper

NM_002439.5

p.A62_P63ins3

c.186_187ins9

1 paper

NM_002439.5

p.A60fs

c.178_179fs

1 paper

NM_002439.5

p.A60_A61delins

c.178_181delinsCCCC

1 paper

NM_002439.5

p.A60_P63del0

c.179_187del9

1 paper

NM_002439.5

p.A59_A60insFs

c.177_178ins8

1 paper

NM_002439.5

p.A60ins2

c.178_179ins6

1 paper

NM_002439.5

p.A60_A65delFs

c.179_195del17

1 paper

NM_002439.5

p.A59G

c.176C>G

4 papers

NM_002439.5

p.A61P

c.181G>C